{"id":7574,"date":"2021-12-01T15:05:42","date_gmt":"2021-12-01T18:05:42","guid":{"rendered":"https:\/\/nis.gl\/?post_type=projekt&#038;p=7574"},"modified":"2021-12-01T15:08:59","modified_gmt":"2021-12-01T18:08:59","slug":"the-effect-on-metabolism-food-intake-and-preferences-of-a-knockout-gene-variant-involved-in-carbohydrate-metabolism","status":"publish","type":"projekt","link":"https:\/\/nis.gl\/da\/projekt\/the-effect-on-metabolism-food-intake-and-preferences-of-a-knockout-gene-variant-involved-in-carbohydrate-metabolism\/","title":{"rendered":"The effect on metabolism, food intake and preferences of a knockout gene variant involved in carbohydrate metabolism\u00a0"},"content":{"rendered":"<p><strong>Research leader:<\/strong> Ninna Senftleber, Postdoc, Steno Diabetes Center Gr\u00f8nland<br \/>\n<strong>\u00d8vrige involverede:<br \/>\n<\/strong>Marit Eika J\u00f8rgensen, Professor, overl\u00e6ge, Steno Diabetes Center Gr\u00f8nland<br \/>\nMichael Lynge Pedersen, L\u00e6gefaglig centerleder, Steno Diabetes Center Gr\u00f8nland<br \/>\nTorben Hansen, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, K\u00f8benhavns Universitet<br \/>\nMatthew Paul Gillum, Associate Professor, Novo Nordisk Foundation Center for Basic Metabolic Research,<br \/>\nK\u00f8benhavns Universitet<br \/>\nMichael Bom Fr\u00f8st, Associate Professor, Design and Consumer Behaviour, K\u00f8benhavns Universitet<br \/>\nLene Seib\u00e6k, Professor, Institut for Sygepleje og Sundhedsvidenskab, Ilisimatusarfik<br \/>\nJette Marcussen, Postdoc, Syddansk Universitet, Institut for Sygepleje og Sundhedsvidenskab, Ilisimatusarfik<br \/>\nAnna Kleist, Afdelings- og Institutleder, Institut for Sygepleje og Sundhedsvidenskab, Ilisimatusarfik<\/p>\n<p><strong>Keywords: <\/strong>Microbiota, sucrase-isomaltase deficiency, sucrose intolerance, diet, Inuit, metabolism, food preferences<\/p>\n<p><strong>Forskningsomr\u00e5de, form\u00e5l og forskningssp\u00f8rgsm\u00e5l:<\/strong><br \/>\nI Inuit befolkninger findes en genetisk variant der g\u00f8r, at folk der har genvarianten ikke kan ford\u00f8je sukker. Man har<br \/>\nset, at disse personer er slankere, har lavere niveauer af fedtstoffer i blodet og muligvis en lavere risiko for<br \/>\nhjertekarsygdom. Vi \u00f8nsker at unders\u00f8ge, hvorfor personer med denne genvariant er sundere end ikke-b\u00e6rere i<br \/>\nGr\u00f8nland ved at unders\u00f8ge forskelle i f\u00f8devarepr\u00e6ferencer, kostindtag og tarmbakterier. Derudover vil vi<br \/>\nunders\u00f8ge effekten af en traditionel gr\u00f8nlandsk kost og en vestlig kost p\u00e5 sukkeroms\u00e6tning og tarmbakterier ved<br \/>\nat give deltagerne de to typer kost i 2*3 dage. Studiet vil hj\u00e6lpe os med at forst\u00e5 det komplekse samspil mellem<br \/>\nlivsstil, genetik, tarmbakterierne og kroppens oms\u00e6tning af n\u00e6ringsstoffer, samt forst\u00e5 konsekvensen af en<br \/>\nvestligg\u00f8relse af kosten for personer med og uden arvelig sukkerintolerance.<\/p>\n<p><strong>Metoder for inklusion af samfundet og formidling overfor smafundet:<\/strong><br \/>\nVi ans\u00e6tter lokale projektmedhj\u00e6lpere i Nuuk, Maniitsoq, og Qasigiannguit, som vil blive opl\u00e6rt og st\u00e5 for flere dele<br \/>\ni studiet; rekruttering af deltagere, informere deltagerne om studiet og deres rettigheder, indsamling af data, bl.a.<br \/>\ngennemf\u00f8re kostinterview, samt til at gennemf\u00f8re den kvalitative brugerinddragelse. Projektmedhj\u00e6lperne f\u00e5r p\u00e5<br \/>\ndenne m\u00e5de erfaring med forskellige aspekter af forskning, og vi f\u00e5r ogs\u00e5 den bedst mulige hj\u00e6lp til projektet ved<br \/>\nat have lokale projektmedhj\u00e6lpere. Vi har derudover igangsat et samarbejde med Brugseni, som \u00f8nsker hj\u00e6lp og<br \/>\nsparring til at arbejde med deres ambition om at opfylde FN&#8217;s verdensm\u00e5l om bedre sundhed og livsstil hos<br \/>\nmedarbejdere og befolkningen.<\/p>\n<p><strong>Projektets start- og slutdato:<\/strong> 01\/11\/2021 &#8211; 31\/03\/2023<\/p>\n<p><strong>Bevilget: <\/strong>99.292,00 kr.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Research leader: Ninna Senftleber, Postdoc, Steno Diabetes Center Gr\u00f8nland \u00d8vrige involverede: Marit Eika J\u00f8rgensen, Professor, overl\u00e6ge, Steno Diabetes Center Gr\u00f8nland Michael Lynge Pedersen, L\u00e6gefaglig centerleder, Steno Diabetes Center Gr\u00f8nland Torben Hansen, Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, K\u00f8benhavns Universitet Matthew Paul Gillum, Associate Professor, Novo Nordisk Foundation Center for Basic Metabolic Research, 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